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Best Smart Drugs to Improve and Boost Brain Function

  • Arcalion

    Arcalion is a brand name for sulbutiamine, which is synthetic thiamine or vitamin B1. Japanese researchers developed sulbutiamine in the 60s for the treatment of beriberi, a condition caused by a vitamin B1 deficiency. Arcalion has also been found to have anti-fatigue and antioxidant effects, which is why athletes often use it to boost their performance. Some studies have shown that Arcalion works as a nootropic, a kind of smart drug that removes fatigue and generalized weakness. Arcalion also facilitates the rehabilitation of patients with mental health issues.

    From $0.77

  • Armodafinil

    Armodafinil is one of the super-effective nootropics and smart drugs used for the treatment of excessive daytime sleepiness caused by conditions such as narcolepsy or obstructive sleep apnea (OSA). It is also used to treat excessive sleepiness caused by shift work sleep disorder (SWSD). Armodafinil is also known to have cognitive benefits, which is why it is often used to boost concentration, focus, motivation, and alertness. It falls under the category of drugs called wakefulness-promoting agents. The exact mechanism is unknown but it works by boosting certain brain chemicals.

    From $0.84

  • Memantine

    Memantine, sold under the brand name Namenda, is recommended for the treatment of moderate to severe dementia associated with Alzheimer’s disease. Please note that it does not cure Alzheimer’s, but it has been found effective at boosting memory, alertness, awareness, and improve the ability to perform daily chores. Meantime has an action on the brain; it works by inhibiting the action of certain brain chemicals that are linked to Alzheimer’s. It belongs to the drugs called NMDA receptor antagonist. NMDA is an ion channel protein found in neurons or nerve cells.

    From $0.77

  • Modafinil

    Modafinil is one of the safe and effective waking drugs advised to patients with narcolepsy because it helps treat excessive sleepiness. It is also used for the treatment of excessive sleepiness due to shift work sleep disorder (SWSD). Off-label, modafinil is used among healthy individuals to increase their alertness, attention, or to mitigate fatigue. The smart drug seems to be an ideal anti-psychotic or anti-fatigue agent. One can use modafinil to stay alert at work, enhance their cognitive functions, and boost their moods.

    From $0.77

  • Modalert

    Modalert is a clinically proven smart drug that is effective in treating narcolepsy, a neurological condition characterized by uncontrollable or excessive daytime sleepiness. It is also advised to treat excessive sleepiness caused by obstructive sleep apnea (OSA) and shift work sleep disorder (SWSD). Modalert is actively composed of modafinil, which is why it is considered one of the versions of generic Provigil. Off-label, people use Modalert to boost their attention, concentration, motivation and focus. It is indeed one of the best smart drugs and nootropics.

    From $1.19

  • Modvigil

    Modvigil is one of the psychostimulants with a wakefulness-promoting effect, which is used to treat excessive sleepiness in people with narcolepsy, obstructive sleep apnea (OSA), and shift work sleep disorder (SWSD). The active drug composition of this medication is modafinil, a smart drug and nootropic. Modafinil has been considered a powerful waking drug in 2003. Many people also use Modvigil to perform well at their academics or work because it has a direct action on the brain, boosting concentration, focus, learning, motivation, memory, and alertness.

    From $0.70

  • Nuvigil

    Nuvigil is recommended to improve wakefulness in patients who have excessive sleepiness due to narcolepsy, obstructive sleep apnea (OSA), or shift work disorder (SWD). Please note that the drug treats excessive sleepiness and not the underlying conditions. Nuvigil is actively composed of a smart drug called armodafinil, which is also known as a nootropic. Many people use Nuvigil to improve their concentration and boost their alertness. It is also advised to people with Alzheimer’s because armodafinil is known to have memory-boosting effects as well.

    From $0.80

  • Provigil

    Provigil contains modafinil, a waking drug prescribed to patients with excessive sleepiness caused by narcolepsy and sleep apnea. However, it is common among individuals who use it to boost their alertness, concentration, focus, motivations, and learning. It is also used to mitigate fatigue. Provigil has the ability to help you stay awake if you have shift work sleep disorder. People who wish to stay awake, enhance their cognitive function, or brighten up their moods can use Provigil. It belongs to drugs called nootropics or smart drugs.

    From $0.82

  • Waklert

    Waklert is a generic version of Nuvigil that contains armodafinil as an active ingredient. It reduces extreme daytime sleepiness caused by narcolepsy and obstructive sleep apnea (OSA). It is also used by people with shift work sleep disorder so they can stay awake during their working hours. Apart from promoting wakefulness, Waklert boosts cognition and improves concentration, focus, attention, alertness, and memory. Waklert is similar to Provigil (modafinil) in terms of indications and pharmacological action.

    From $1.47

Smart drugs, aka nootropics, such as modafinil, armodafinil, and piracetam are commonly used to augment cognitive function and ability. Current nootropic agents offer mild improvements in cognitive function, but it seems like more effective compounds are on the cards and their off-label use as smart drugs will increase. One specific group that uses these drugs is healthy students so they can give their best at academics.

Cognitive enhancers are generally approved for the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, and dementia. For instance, modafinil (Provigil) and armodafinil (Nuvigil) have been approved by the FDA for the treatment of excessive daytime sleepiness caused by narcolepsy. These drugs are prescribed off-label for enhancing concentration, focus, motivation, learning, attention, alertness, and memory because they tend to have wakefulness-promoting effects.

Using prescription smart drugs to improve cognition in healthy people has gained a lot of attention from neuroscientists. Experts claim that the use of neuro-enhancement drugs is widespread and has been increasing. One should note that smart drugs are prescription-only drugs, while some of them are schedule IV controlled substances, which are to be used under the supervision of a medical professional. Smart drugs use is becoming widespread among office-goers to perform well under pressure at their workplaces.

Fast Facts about Smart Drugs

  • Smart drugs are a type of therapeutic agents recommended to improve your intellectual capacity, especially if you are suffering from any neurological or psychological disorders.
  • The use of smart drugs to boost memory and concentration is medically called pharmacological cognitive enhancement (PCE), which has significantly increased.
  • In the United States, more than nearly 30% of people reported using smart drugs for PCE at least in their lives.
  • It is important to note that the long-term effects of nootropics on otherwise healthy brains are unknown, raising their safety concerns.
  • Some researchers believe there is a future for smart drugs, as drugs like modafinil and armodafinil are being used globally to boost cognitive ability.

Prescription Smart Drugs

Doctors may recommend a nootropic or prescription smart drug to treat certain medical conditions. Usually, nootropics are a type of stimulant, for instance, amphetamines that help treat ADHD, modafinil/armodafinil that treat narcolepsy, memantine for memory loss, etc. Prescription smart drugs include modafinil (Provigil), armodafinil (Nuvigil), amphetamines (Adderall), methylphenidate (Ritalin), and memantine (Axura).

While these nootropics are found to be effective in treating specific neurological conditions, people should take them under a prescription. Like all prescription medications, these smart drugs carry a risk of side effects and drug interactions so people should take them under the supervision of a doctor. Common side effects associated with prescription smart drugs include high blood pressure, increased heart rate, insomnia, and addiction.

OTC Smart Drugs

Over-the-counter (OTC) smart drugs are referred to as natural/synthetic supplements that boost overall mental performance. OTC nootropics include caffeine. L-theanine, omega-3 fatty acids, Ginkgo Biloba, Panax ginseng, Rhodiola, and creatine. Other OTC nootropics include racetams, such as piracetam, pramiracetam, phenylpiracetam, and aniracetam. One can buy OTC smart drugs online without providing a prescription.

Benefits of Smart Drugs

Most studies have listed a few potential cognitive-enhancing benefits of using smart drugs like modafinil, armodafinil, methylphenidate, dexamphetamine, or piracetam. The benefits include an overall improvement in brain functioning, improved focus and concentration, enhanced academic performance, and improved memory. Nootropics like Provigil and Nuvigil showed the benefits of staying awake. They also reduce fatigue and increase alertness.

Potential Risks of Smart Drugs

Like all synthetic drugs, smart drugs do cause a few health risks or side effects. Some of the most common side effects of nootropics include insomnia, drug addiction or drug dependence, and substance abuse. Some people who use smart drugs may have mental health issues such as anxiety. Other potential risks include headache, heart rhythm problems, and loss of appetite.

Of all smart drugs, it has been found that modafinil and armodafinil are not the drugs that cause drug addiction, which is why they are considered safe in most people. Besides, modafinil and armodafinil do not cause withdrawal symptoms even after using them for a certain period of time.

Influence of Smart Drugs

Nootropics are well-known compounds that enhance your cognitive performance. Smart drugs usually work by increasing the secretion of certain brain chemicals, called neurotransmitters. They improve mental function such as creativity, memory, motivation, focus, and attention. The influence of nootropics is on the brain, which has been studied widely. The drugs boost brain performances via several mechanisms.

Also called 'brain boosters' or 'memory-enhancing drugs', nootropics have been found to have a good influence on people with memory disorders, like Alzheimer’s, Parkinson’s, as well as Huntington’s diseases. These neurological disorders are a result of impaired neurological pathways. And nootropics repair the impaired neurological pathways.


The use of smart drugs to boost intelligence, memory, and cognitive functioning has attracted the attention of many people, even medical professionals. Nootropics are a class of pharmaceutical agents legally available in many countries to treat mental health issues. Smart drug use is often compared to steroid use in a student group. Surveys have found that many people use smart drugs casually to increase their learning capacity, intelligence, and enhance their memory. Students take nootropics to be smarter, others use it to perform well under pressure at workplaces.